Aqueous humor formation

The ciliary processes are the sites of aqueous humor production. In the healthy eye, flow of aqueous humor against resistance generates an average intraocular pressure of approximately 15mmHg [ 5 ]. Intraocular pressure is a property of aqueous humor. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License http: The epithelium of the ciliary processes has two layers: However, increased interocular pressure is neither sufficient nor necessary for development of primary open angle glaucoma, although it is a major risk factor.

Aqueous humor is produced at an average rate of 2. Aqueous humor formation and secretion into the posterior chamber result from active secretion, which takes place in the double-layered ciliary epithelium ultrafiltration simple diffusion Active secretion, or transport, consumes energy to move substances against an electrochemical gradient and is independent of pressure.

Each of the 80 or so processes contains a large number of capillaries, which are supplied mainly by branches of the major arterial circle of the iris. During sleep circulating epinephrine is decreased which may in part account for the reduction in production but is Aqueous humor formation the sole factor for the circadian cycle.

If the fluid is leaking, due to collapse and wilting of cornea, the hardness of the normal eye is therefore corroborated. The non-pigmented ciliary epithelium represents the continuation of the retina; the pigmented epithelium, the continuation of the retinal pigmented epithelium [ 9 ].

This article has been cited by other articles in PMC. Ultrafiltration refers to a pressure-dependent movement along a pressure gradient. Although no anatomic evidence has been found identifying autonomic innervation to the epithelia, animal studies have found some alteration in production volumes in response to manipulations of the autonomic signal.

Ascorbate concentration is approximately 20 times higher in aqueous than in blood plasma and must be actively transported into the aqueous.

It is this hydrostatic pressure which keeps the eyeball in a roughly spherical shape and keeps the walls of the eyeball taut. In the years to come, this disease is expected to affect even greater populations, especially as the elderly population grows disproportionately [ 3 ].

IOP is necessary to inflate the eye and maintain the proper shape and optical properties of the globe. TM can be divided in three components: Although the ultrafiltration process can be influenced by changes in IOP the effect on the rate of formation is slight.

The relationship between secretion and ultrafiltration is not known. Vision loss in most forms of glaucoma is related to elevated IOP with subsequent injury to the optic nerve.

Abstract Glaucoma is a family of optic neuropathies which cause irreversible but potentially preventable vision loss. Diffusion is the passive movement of ions across a membrane related to charge and concentration. Relative to plasma, aqueous humor has a: Slight hypertonicity and acidity pH 7.

This alteration occurs across the hyaloid face of the vitreous, the surface of the lens, the blood vessels of the iris, and the corneal endothelium and is secondary to other dilutional exchanges and active processes. The primary difference between blood plasma and aqueous is in the concentration of ascorbate and of protein.

Small variations in the production or outflow of aqueous humour will have a large influence on the intraocular pressure. In humans, aqueous humor has an excess of hydrogen and chloride ions, an excess of ascorbate, and a deficit of bicarbonate relative to plasma. In the ciliary processes, the hydrostatic pressure difference between capillary pressure and IOP favors fluid movement into the eye, whereas the oncotic gradient between the two resists fluid movement.

Secretion of aqueous humor and regulation of its outflow are physiologically important processes for maintaining IOP in the normal range.

Aqueous Humour: Anatomy & Physiology

Presence of immunoglobulins indicate a role in immune response to defend against pathogens. The corneoscleral meshwork extends from the scleral spur to the anterior wall of the scleral sulcus and is the most extensive portion of the TM.

Composed of muscle, blood vessels and epithelia. Occupying the innermost and anterior most portion of this structure, in a region called pars plicata, are the ciliary processes.

Diffusion and ultrafiltration are both passive mechanisms, with lipid- and water-soluble substances from the capillary core traversing the stroma and passing between pigmented epithelial cells and limited by the tight junctions of the non-pigmented epithelial cells Active transport secretion — water-soluble substances of larger size or greater charge are actively transported across the cell membrane, requiring the expenditure of energy; Na-K ATPase and glycolytic enzymes are present in nonpigmented epithelial cells.

Aqueous Humor Dynamics: A Review

Glaucoma is often classified into primary open-angle POAGprimary angle-closure PACGsecondary angle-closure, and secondary open-angle, congenital and juvenile glaucomas.Aqueous Humor.

A. Composition: Aqueous is a transparent, colorless solution continuously formed from plasma by the epithelial cells of the ciliary processes. It composition and formation resembles cerebrospinal fluid.

Notable features of its composition include: 1. Very low protein concent ration (% of plasma). Aqueous humor. Aqueous humor is an optically clear, slightly alkaline ocular fluid that is continuously formed (~ μL/min in humans) from plasma by epithelial cells of ciliary body [34].

Three different processes – diffusion, ultrafiltration and active secretion – contribute to the chemical composition and formation of aqueous humor.

Aqueous humor formation is a biological process that is subject to circadian rhythms. Aqueous humor is formed by the ciliary processes, each of which is composed of a double layer of epithelium over a core of stroma and a rich.

Aqueous humour is continuously produced by the ciliary body and hence has to be drained out. The drainage route for aqueous humour flow: the posterior chamber, then the narrow space between the posterior iris and the anterior lens, through the pupil to enter the anterior chamber, the trabecular meshwork.

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Sep 03,  · Aqueous Humor Dynamics: A Review. Manik Goel, Renata G Picciani, X C+U where F is the rate of aqueous humor formation, P i is the intraocular pressure, P e is the episcleral venous pressure, C is the tonographic facility of outflow and U is the pressure insensitive parameter to symbolize uveoscleral outflow).

Aqueous humour is continually produced by the ciliary processes and this rate of production must be balanced by an equal rate of aqueous humour drainage. Small variations in the production or outflow of aqueous humour will have a large influence on the intraocular pressure.

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Aqueous humor formation
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